Comments on: On the UK’s DNA Database, Part 1 http://www.genetic-inference.co.uk/blog/2009/05/on-the-uks-dna-database-part-1/ Thu, 26 Aug 2010 23:21:07 +0000 hourly 1 http://wordpress.org/?v=3.0.1 By: Luke http://www.genetic-inference.co.uk/blog/2009/05/on-the-uks-dna-database-part-1/comment-page-1/#comment-299 Luke Mon, 18 May 2009 22:44:44 +0000 http://www.genetic-inference.co.uk/blog/?p=379#comment-299 So, for things like trisomy you'd probably just get too many peaks, and the reading would be dismissed (filed as a Partial Profile). Chemerism is more tricky; by default, they don't test for it (as they only take one tissue type), so only one genotype would go on the database: that does leave the potential for false negatives. If they did get a confirmed chimera, I doubt they'd have a way of storing that on the database without just creating one entry for each profile. However, I'd have thought that chimerism is so rare that it isn't worth having a specific plan for. So, for things like trisomy you’d probably just get too many peaks, and the reading would be dismissed (filed as a Partial Profile).

Chemerism is more tricky; by default, they don’t test for it (as they only take one tissue type), so only one genotype would go on the database: that does leave the potential for false negatives. If they did get a confirmed chimera, I doubt they’d have a way of storing that on the database without just creating one entry for each profile.

However, I’d have thought that chimerism is so rare that it isn’t worth having a specific plan for.

]]> By: Rhan http://www.genetic-inference.co.uk/blog/2009/05/on-the-uks-dna-database-part-1/comment-page-1/#comment-298 Rhan Mon, 18 May 2009 21:32:12 +0000 http://www.genetic-inference.co.uk/blog/?p=379#comment-298 One thing that piques my interest is how the database might handle chimeric individuals. I'm guessing trisomies and other irregularities wouldn't have such a noticeable effect. One thing that piques my interest is how the database might handle chimeric individuals. I’m guessing trisomies and other irregularities wouldn’t have such a noticeable effect.

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