Tag Archives: disease

On GSK’s Announcement

Hello again, reader; we have been seeing a lot of each other this week. This is my promised post on GSK’s recent announcement of a set of initiatives to help fight disease in the 50 poorest developing countries. I’ll go through some background about GSK’s business model and what has been happening to them recently, and then we’ll take a look through what the responses to the initiatives have been, and what my take on it is.
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On GSK’s Announcement - Prelude

Good evening, reader. As you may or may not have seen, all the newspapers today are reporting on the announcement by the drug company GlaxoSmithKline that they are starting a set of initiatives to help fight disease in the 50 poorest developing countries. Specifically, they have pledged to cap prices in these country at 25% of the UK price (which is cheep, but not as cheep as generic, non-branded drugs), to re-invest 20% of profits in these countries as aid and health care development, and to form a ‘patent pool’ to allow other companies and research bodies access to their patents for the development of drugs to aid the developing world (but this pool would not include HIV patents relating to HIV drugs, which is odd).

GSK has a bit of a tainted history, with a few things in their past to be ashamed of. For instance, they were one of the 39 pharmaceutical companies that attempted to sue South Africa top stop them importing genetic drugs, about which the CEO of GSK understatedly commented “I don’t think anybody can claim that was handled well”. They were also accused of covering up evidence that their antidepressant drug Paroxetine was addictive. They have recently been cutting down on research (as well as generally cutting jobs across the board); I’m not sure if that is related to their current proposals. Either way, I could imagine that clawing back a bit of good PR would be on the cards for GSK management. I also don’t rule out the possibility that Andrew Witty, who has only been CEO since May of last year, has a genuine desire to help the needy, and is willing to persuade his shareholders to take a hit in profits for the greater good.

I haven’t been able to find much out about this. The newspapers are reporting plenty, but I couldn’t find a GSK press release about it, and while Doctors Without Borders were called for comment some of the newspapers, their website doesn’t currently have anything on it. Likewise, I haven’t been able to find much in the way of reactions throughout the blogosphere yet. Thus, this post is just a brief prelude, without much in the way of analysis; I will try and get more information in the next few days, and put up a post with more on what is going on, and how it relates to the structure and function of the pharmaceutical industry in general.

On Disease Association

Hello again, my loyal blogventurer. The hectic nature of my life continues, though to my joy genomes are starting to fall into place (computationally, that is, not by insemination. Though doubtless that has also been going on. If not, god help us all). However, I think all this business is leading to general mental decline. Yesterday, in a fit of flustered Britishness, I thanked an ATM after using it, an event which, on retelling. triggering a ‘not-adapted-to-the-modern-world five’ from a quick-witted colleague.

Rambling introductory material aside, a few things have occured in the past week that have rekindled my passion for medical genetics. A few of us put together a talk on monoclonal antibodies (an awesome medical technology, which if you are lucky I may talk about in the future), and I signed up to work on disease gene association in the coming months. The latter I have a special affection for, an affection which I shall now point at you.
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On Bayes and Me

This post carries on from my previous excursion into Bayesian statistics.

Bayesian Science

A mathematician friend once told me that Bayesian inference is the type of inference that fits in most readily with the scientific method (that being the method I am most prepared to use in the majority of situations). It is true that a Bayesian inference, if done properly, represents a mathematical version of an idealised scientific inference - we have some explicitly stated prior beliefs, based on previous evidence, and we look for data, in the form of experiments or observations, which are combined to form an inference. Lovely.
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On Eugenics

I hope that you will tolerate this post, as it is mostly me thinking out loud. Thinking out-loud, whats more, about a potentially distressing subject, namely that of the relationship between the history of biology, genetics and statistics (which are, after all, tied tightly together) and eugenics - the project of increasing the fitness of the human gene pool, by controlling the breeding or death rates of various parts of the population.

The problem I have is that many people that I would call my heroes, or at least people along whose intellectual footpaths I wander (Ronald Fisher, Francis Galton, Karl Pearson, John Maynard Keynes) supported the eugenics movement. Am I to assume that all these people, while intellectual giants, were monsters or fools? Can we (you and I, for by embarking on this journey with me you too, kind reader, must shoulder my burden) find where these people went wrong, and what can we learn by looking at those people who shunned eugenics?

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On Bayes

This is a backdated post, written more recently than the date claims, in order to give the impression that this blog has History. This is a dirty trick, but a necessary one, and I know that you, gentle reader, will keep my secret safe.

I have a feeling that, in some sense, someone in my position (a position which you, my noble blog adventurer, are likely to learn more of in time) should have on record a position on the Bayesian Issue. I will start this by dedicating a post to explaining The Bayesian Issue, and then later on having a post on where I stand on it.

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