Tag Archives: politics

The Economist Mangles Disease Genetics

The Economist has a rather distressingly bad article by the evolutionary psychologist Geoffrey Miller, about the supposed general failure in human disease genetics over the last 5 years. The thesis is that Genomes Wide Association Studies (GWAS) for common diseases have been a failure that geneticists are trying to keep hidden, and that the new techniques required to solve the problem of disease genetics will raise ‘politically awkward and morally perplexing facts’ about the different traits and evolutionary histories of races. The former claim is pretty much the same as Steve Jones Telegraph article earlier this year, and is just as specious. I will look at both claims separately.

A quick point of terminology: Miller uses ‘GWAS’ to refer to studies that look for disease association in common variants using a genotyping chip, and acts as if sequencing studies are not, in fact, GWAS. In fact, a sequencing association study is just another type of GWAS, just looking at a larger set of variants.
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Unbelief, Class and Bad Statistics

I like to read the Comment is free: Belief section of the Guardian website; it has comment pieces on a pretty large range of religious matters, which satisfies both my “reading about religious affairs” and “reading things that annoy me” urges (in particular, I find a bit of an odd pleasure in reading the regular posts by Andrew Brown, a man who has a wonderful habit of saying things I would probably agree with in such a smug, sneering style that I can’t help but disagree).

Today there is a post up called Religion And Learning: what do we know, by Nick Spencer of the religious thinktank Theos. It feeds on from a somewhat substance-light Andrew Brown post claiming that atheism (or ‘new atheism’, or some ill-defined form of non-belief) is becoming a way of the upper middle class setting themselves apart from the Daily Mail-reading working class.

Nick Spencer’s article attempts to shed some light on the relationship between class and religious belief by looking at the relationship between NRS social classes and belief in God, based on some Theos data from their recent Darwin report. The report, unfortunately, doesn’t tell us very much; it says that Atheists tend to come from higher social grades (AB), and theists tend to come from lower social grades (DE); this was already well know.

Spencer goes on to look at the social classes of converts; he finds that converts to theism tended to come from the roughly the same classes as atheists (ABC), and that converts to atheism tended to come from the same classes as theists (DE). This is unsurprising, it basically says that there is no real social indication of conversion; it is more or less a random process, with atheists going to theists and vice versa more or less independent of social class. It would be interesting to follow up these converts over larger periods of time, or to break it down into recent and older conversions, to see whether converting to a religion causes a change in class, but so far we have no evidence for this. So, in conclusion, the data doesn’t tell us anything interesting about how religion and class or education beyond what we already knew; if anything, it tells us that class or education aren’t really playing much of a factor in conversion.

Or, that is the conclusion that any non-reaching person would draw. What is odd is that Nick Spencer uses this essentially Null result to argue that some sort of revolutionary change on the nature of atheism:

On a less grand scale, the data suggest that the effect of vocal atheism over the last decade has been to reach successfully into previously uncharted demographic territory (witness The God Delusion’s sales figures) but at the cost of losing some of its intellectual credibility (the critical review of The God Delusion in the London Review of Books, for example).

If this is happening, we might expect to see atheism become increasingly “religious” in its composition if not in its size.

So, according to Nick Spencer, the expected class distribution of converts if there is no relationship between class and conversion is an indicator of a grand, sweeping change in the nature of atheism, and we should all be prepared for atheism to become a ‘religion-like’ mass movement of unthinking godlessness. This is completely the opposite conclusion that I have made from the same data; that non-belief is going on the same as it always has (as far as I can see, the current bunch of non-believers are no more outspoken or populist than Carl Sagan, Richard Feynman, Bertrand Russell and Thomas Huxley), and there is no particular evidence that anything new is going on in unbelief.

On the UK’s DNA Database, Part 1

This is the first part of a double post in the UK National DNA Database.

The newspapers have been flaring up over the issue of the National DNA Database (NDNAD) over the last week. The NDNAD, which is the largest such database in the world, was denounced by the European Court of Human Rights as unjustified, as it holds information on innocent people, and routinely uses them to investigate crimes. The govournment proposed certain changes, the most reported of which is the decision to only hold innocent people’s DNA for 6-12 years. Liberty’s Shami Chakrabarti denounced the policy, saying “wholly innocent people – including ­children – will have their most intimate details stockpiled for years”.

The blogosphere has also been making interesting noises about this: Iain Brassington at the BMJ’s Journal of Medical Ethics blog posts about the ethical problems with the database, and over at Liberal Conspiracy Denny de la Haye talks about how the government’s proposed policy changes fail to address the issues raised by the Court of Human Rights.

I thought it might be worth researching exactly what information is held on the NDNAD, and what this information could be used for. This post turned out to be pretty long, so I’ve split it up into two posts: this first one asks exactly what the genetic profiling involves, and what information is recorded. The second post, which I will put up on Friday, asks how the information is used currently, and what it could potentially be used for in the wrong hands.
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On Becoming The Man You Want To Be

In my strictly rationed free time, I liked to visit Natural History Museums, and it being Darwin Year and all, I have in the last month or so visited two Darwin-themed exhibits. [I do realise that the preceding statement may be one of the least surprising revelations that has ever been divulged in the long history of this blog.] I feel that I am starting to get a general feeling for the man, and what drove him. One thing that I find interesting is how he never intended to revolutionize biology, and paradoxically why that made him the perfect man to do so.
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On GSK’s Announcement

Hello again, reader; we have been seeing a lot of each other this week. This is my promised post on GSK’s recent announcement of a set of initiatives to help fight disease in the 50 poorest developing countries. I’ll go through some background about GSK’s business model and what has been happening to them recently, and then we’ll take a look through what the responses to the initiatives have been, and what my take on it is.
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On GSK’s Announcement - Prelude

Good evening, reader. As you may or may not have seen, all the newspapers today are reporting on the announcement by the drug company GlaxoSmithKline that they are starting a set of initiatives to help fight disease in the 50 poorest developing countries. Specifically, they have pledged to cap prices in these country at 25% of the UK price (which is cheep, but not as cheep as generic, non-branded drugs), to re-invest 20% of profits in these countries as aid and health care development, and to form a ‘patent pool’ to allow other companies and research bodies access to their patents for the development of drugs to aid the developing world (but this pool would not include HIV patents relating to HIV drugs, which is odd).

GSK has a bit of a tainted history, with a few things in their past to be ashamed of. For instance, they were one of the 39 pharmaceutical companies that attempted to sue South Africa top stop them importing genetic drugs, about which the CEO of GSK understatedly commented “I don’t think anybody can claim that was handled well”. They were also accused of covering up evidence that their antidepressant drug Paroxetine was addictive. They have recently been cutting down on research (as well as generally cutting jobs across the board); I’m not sure if that is related to their current proposals. Either way, I could imagine that clawing back a bit of good PR would be on the cards for GSK management. I also don’t rule out the possibility that Andrew Witty, who has only been CEO since May of last year, has a genuine desire to help the needy, and is willing to persuade his shareholders to take a hit in profits for the greater good.

I haven’t been able to find much out about this. The newspapers are reporting plenty, but I couldn’t find a GSK press release about it, and while Doctors Without Borders were called for comment some of the newspapers, their website doesn’t currently have anything on it. Likewise, I haven’t been able to find much in the way of reactions throughout the blogosphere yet. Thus, this post is just a brief prelude, without much in the way of analysis; I will try and get more information in the next few days, and put up a post with more on what is going on, and how it relates to the structure and function of the pharmaceutical industry in general.